商品编号


6155



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

5 mg

商品信息

Description:
Negative Control for MZ1

Chemical Name:
(2
S
,4
S
)-1-((
S
)-2-(tert-butyl)-17-((
S
)-4-(4-chlorophenyl)-2,3,9-trimethyl-6
H
-thieno[3,2-
f
][1,2,4]triazolo[4,3-
a
][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-
N
-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Negative Control for MZ1 (Cat.No. 6154). Exhibits no significant VHL binding affinity.



Licensing Information

Sold under licence from the University of Dundee



External Portal Information

Chemicalprobes.org
is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MZ 1 is reviewed on the chemical probes website.



Technical Data



M. Wt

1002.64



Formula

C
49
H
60
ClN
9
O
8
S
2




Storage

Store at -20°C



Purity

≥98% (HPLC)



CAS Number

1797406-72-4



PubChem ID

124201820



InChI Key

PTAMRJLIOCHJMQ-HADAFJFFSA-N



Smiles

CC1=C(C2=C(N3C(C)=NN=C3[C@@H](N=C2C4=CC=C(C=C4)Cl)CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5C[C@H](C[C@H]5C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)O)=O)=O)=O)S1)C



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

100.26

100



ethanol

100.26

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
1002.64
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

1 mL

4.99 mL

9.97 mL



5 mM

0.2 mL

1 mL

1.99 mL



10 mM

0.1 mL

0.5 mL

1 mL



50 mM

0.02 mL

0.1 mL

0.2 mL






Molarity Calculator






Molarity Calculator

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Reconstitution Calculator






Reconstitution Calculator



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Dilution Calculator






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Zengerle

et al
(2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS.Chem.Biol.
10
1770 PMID: 26035625




Keywords: cis MZ 1, supplier, cis, MZ1, MZ1, PROTAC, Proteolysis, targeted, chimeras, Bromodomain, BRD2, BRD3, BRD4, BET, proteins, JQ1, VHL, E3, ubiquitin, ligase, HIF-alpha, HIF-a, HIF-α, Ubiquitin, E3, Ligases,
Tocris
Bioscience