商品编号


CHI-HF-210CD36-C100



品牌


Adipogen



公司


Adipogen



公司分类


Immunology



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

Platelet Glycoprotein 4; Fatty Acid Translocase; FAT; SCARB3; GP88; Glycoprotein IV; GPIV; Glycoprotein IIIb; GPIIIb; Thrombospondin Receptor



Product Type

Protein



Properties



Source/Host

HEK 293 cells



Sequence

The extracellular domain of human CD36 (aa 30-439) is fused to the N-terminus of the Fc region of human IgG1.



Crossreactivity

Human



Purity

≥98% (SDS-PAGE)



Endotoxin Content

<0.06eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">0.06eu>



Reconstitution

Reconstitute with sterile water to a concentration of 100?g/ml.
Add 1X PBS to the desired protein concentration.



Formulation

Lyophilized from 0.2μm-filtered solution in PBS.



Other Product Data

NCBI reference AAH08406.1: CD36 (human)



Declaration

Manufactured by Chimerigen.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





CD36 (Cluster of Differentiation 36) is also known as platelet membrane glycoprotein IV (GPIV), fatty acid translocase (FAT), thrombospondin receptor, collagen receptor and scavenger receptor class B, member 3 (SRB3), is a member of the class B scavenger receptor family of cell surface proteins. The human CD36 gene encodes a single chain 472 amino acid residue protein containing both a N- and a C-terminal cytoplasmic tail and an extracellular loop. CD36 is found on platelets, erythrocytes, monocytes, differentiated
ADI
pocytes, mammary epithelial cells, spleen cells and some skin microdermal endothelial cells. CD36 is a multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of protein-nature like thrombospondin-1 (TSP1), fibronectin, collagens I and IV or amyloid-β as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids (LCFA), high density lipoprotein (HDL), phosphatidylserine, apoptotic cells and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. This internalization is independent of macropinocytosis and occurs by an actin dependent mechanism requiring the activation Src-family kinases, JNK and Rho-family GTPases. Cellular responses to these ligands are involved in angiogenesis, inflammatory response (through TLR4-6 and TLR2-6 signaling), fatty acid metabolism, taste and dietary fat processing in the intestine.