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Sigma-Aldrich/Fmoc-Asp-ODmab/8520790001/8520790001

多肽
Sigma-Aldrich/Fmoc-Asp-ODmab/8520790001/8520790001


商品编号


8520790001



品牌


西格玛奥德里奇(Sigma-Aldrich)



公司


Merck & Co., Inc.



公司分类


Chemistry



Size

8520790001

商品信息

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Synonym:

N-α-Fmoc-L-aspartic acid α-4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-amino} benzyl ester

CAS Number
172611-77-7



Linear Formula
C??H??N?O?



Molecular Weight
666.77?g/mol

Properties:

Related Categories

Amino Acids & Derivatives, Aspartic Acid, Chemical
BIOLOG
y, Chemical Synthesis, Peptide Chemistry
Description:
Background information

Quasi-orthogonally-protected Asp derivative.
The Dmab group can be removed selectively in the presence of tBu-based protecting groups by treatment with 2% hydrazine in DMF [1], making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS or for library synthesis.
Occasionally sluggish cleavage of the aminobenzyl moiety is observed [2, 3]. In these instances, washing the support with 20% DIPEA in DMF/water (9:1) [2] or HCl in dioxane [4] has been found to be efficacious.
For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(ivDde) and Asp(ODmab) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.
To avoid aspartimide formation, it is advisable to employ an Hmb- or Dmb-protected derivative for introduction of the preceding residue.
For applications of this derivative in the synthesis of cyclic peptides, see references [5 - 7].
The product number for this product was previously 04-12-1176.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
Safety:

HS Code?

2924 29 70



Storage class?

10 - 13 Other liquids and solids



WGK?

WGK 2 water endangering

上一篇 LKT/[ASP371]-TYROSINASE (369-377), HUMAN/T9974/1 mg  下一篇 Sigma-Aldrich/Fmoc-Asp(OBzl)-OH/47593-5G-F/5GF

产品货号:2128.8

2128.8 ¥
11至15个工作日送达