Sigma-Aldrich/Fmoc-Asp-ODmab/8520790001/8520790001
多肽
商品编号
8520790001
品牌
西格玛奥德里奇(Sigma-Aldrich)
公司
Merck & Co., Inc.
公司分类
Chemistry
Size
8520790001
商品信息
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Synonym:
N-α-Fmoc-L-aspartic acid α-4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-amino} benzyl ester
CAS Number
172611-77-7
Linear Formula
C??H??N?O?
Molecular Weight
666.77?g/mol
Properties:
Related Categories
Amino Acids & Derivatives,
Aspartic Acid,
Chemical
BIOLOG
y,
Chemical Synthesis,
Peptide Chemistry
Description:
Background information
Quasi-orthogonally-protected Asp derivative.
The Dmab group can be removed selectively in the presence of tBu-based protecting groups by treatment with 2% hydrazine in DMF [1], making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS or for library synthesis.
Occasionally sluggish cleavage of the aminobenzyl moiety is observed [2, 3]. In these instances, washing the support with 20% DIPEA in DMF/water (9:1) [2] or HCl in dioxane [4] has been found to be efficacious.
For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(ivDde) and Asp(ODmab) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.
To avoid aspartimide formation, it is advisable to employ an Hmb- or Dmb-protected derivative for introduction of the preceding residue.
For applications of this derivative in the synthesis of cyclic peptides, see references [5 - 7].
The product number for this product was previously 04-12-1176.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
Safety:
HS Code?
2924 29 70
Storage class?
10 - 13 Other liquids and solids
WGK?
WGK 2 water endangering
产品货号:2128.8