商品编号


A5279-10 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

10 mg

商品信息

Product ID
A5279
Cas No.
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Angiotensin II (AT II) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). AT II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels; this results in contraction and vasoconstriction, increasing blood pressure. AT II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney. Here, AT II increases reabsorption of Na+ and HCO3- and excretion of H+, increasing blood volume and pH and further increasing blood pressure.
Product Info
Purity
≥95%
Formula
C
24
H
37
N
7
O
8
Formula Wt.
551.6
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
Info Sheet
A5279 Info Sheet PDF
References
De Giusti VC, Ciancio MC, Orlowski A, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411. PMID: 24478712.
Moon JY. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-45. PMID: 24627703.