商品编号


A5277-10 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

10 mg

商品信息

Product ID
A5277
Cas No.
68521-88-0
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Angiotensin II (AT II) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). AT II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels; this results in contraction and vasoconstriction, increasing blood pressure. AT II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney. Here, AT II increases reabsorption of Na+ and HCO3- and excretion of H+, increasing blood volume and pH and further increasing blood pressure.
Product Info
Cas No.
68521-88-0
Purity
≥95%
Formula
C
50
H
71
N
13
O
12
Formula Wt.
1046.19
IUPAC Name
aceticacid;3-amino-4-[[1-[[1-[[1-[[1-[[1-[2-[(1-carboxy-2-phenylethyl)carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
Synonym
Hypertensin II
Solubility
Soluble in water or 5% acetic acid.
Appearance
White to off white powder
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
MSD
S
A5277
MSD
S PDF
Info Sheet
A5277 Info Sheet PDF
References
De Giusti VC, Ciancio MC, Orlowski A, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411. PMID: 24478712.
Moon JY. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-45. PMID: 24627703.