商品编号


H2980-2.5 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

2.5 mg

商品信息

Product ID
H2980
Cas No.
330936-69-1
Purity
≥95%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Humanin is an endogenous peptide that exhibits anti-apoptotic and neuroprotective activities. Humanin is overexpressed in some cancers and could poss
IBL
y be used as a bio
Marker
. In neurons undergoing ischemia/reperfusion, humanin decreases levels of lactate dehydrogenase and malondialdehyde, decreases the formation of karyopyknotic nuclei, and increases the activity of superoxide dismutase (SOD), increasing cell vi
ABI
lity and survival. In other cellular models, humanin activates formyl peptide receptor-like receptors 1 and 2 (FPRL1/2), inhibiting Bax-dependent apoptosis and suppressing JNK-mediated cell death. Humanin also inhibits amyloid-β (Aβ)-induced neuronal death in vitro and its effects in animal models of Alzheimer’s disease.
Product Info
Cas No.
330936-69-1
Purity
≥95%
Formula
C
119
H
204
N
34
O
32
S
2
Formula Wt.
2687.28
Appearance
White to off white powder
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
Info Sheet
H2980 Info Sheet PDF
References
Mottaghi-Dastjerdi N, Soltany-Rezaee-Rad M, Sepehrizadeh Z, et al. Genome expression analysis by suppression subtractive hybridization identified overexpression of Humanin, a target gene in gastric cancer chemoresistance. Daru. 2014 Jan 8;22(1):14. PMID: 24401285.
Zhao ST, Huang XT, Zhang C, et al. Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase. Neu
Roche
m Res. 2012 Jan;37(1):153-60. PMID: 21935731.
Zapa?a B, Kaczyński ?, Kie?-Wilk B, et al. Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties. Pharmacol Rep. 2010 Sep-Oct;62(5):767-77. PMID: 21098860.
Niikura T, Tajima H, Kita Y. Neuronal cell death in Alzheimer's disease and a neuroprotective factor, humanin. Curr Neuropharmacol. 2006 Apr;4(2):139-47. PMID: 18615127.
Zhai D, Luciano F, Zhu X, et al. Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak. J Biol Chem. 2005 Apr 22;280(16):15815-24. PMID: 15661737.
Ying G, Iribarren P, Zhou Y, et al. Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor. J Immunol. 2004 Jun 1;172(11):7078-85. PMID: 15153530.