商品编号


K1978-5 g



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

5 g

商品信息

Product ID
K1978
Cas No.
74103-07-4
Purity
≥98%
Description
Product Info
Shipping and Storage
Downloads
References

Description
Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory and analgesic activities. Ketorolac inhibits COX-1 and COX-2. In vivo, admi
NIST
ration of ketorolac prevents the spinal injury-induced increase of protease-activated receptor 1 (PAR1) levels and decreases activation of spinal astrocytes, resulting in decreased allodynia. In spinal neurons, ketorolac decreases substance P-, calcitonin gene-related peptide- and dynorphin-immunoreactivity. Additionally, this compound decreases expression of phosphodiesterase type 4 (PDE4D).
Product Info
Cas No.
74103-07-4
Purity
≥98%
Formula
C
15
H
13
N
2
O
3
? C
4
H
11
NO
3
Formula Wt.
376.40
IUPAC Name
2-amino-2-(hydroxymethyl)propane-1,3-diol;5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
Melting Point
165-167°C
Appearance
White to off white powder
Shipping and Storage
Store Temp
Ambient
Ship Temp
Ambient
Downloads
Info Sheet
K1978 Info Sheet PDF
References
Dong L, Smith JR, Winkelstein BA. Ketorolac reduces spinal astrocytic activation and PAR1 expression associated with attenuation of pain after facet joint injury. J Neurotrauma. 2013 May 15;30(10):818-25. PMID: 23126437.
Bendixen KH, Baad-Hansen L, Cairns BE, et al. Effects of low-dose intramuscular ketorolac on experimental pain in the masseter muscle of healthy women. J Orofac Pain. 2010 Fall;24(4):398-407. PMID: 21197512.
Wang XM, Hamza M, Gordon SM, et al. COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory pain. Clin Pharmacol Ther. 2008 Jul;84(1):39-42. PMID: 18288087.
Ma W, Eisenach JC. Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation. Neuroscience. 2003;121(3):681-90. PMID: 14568028.