商品编号


L0248-1 mg



品牌


LKT Labs



公司


LKT Laboratories, Inc



公司分类


Peptides



Size

1 mg

商品信息

Product ID
L0248
Cas No.
110590-64-2
Purity
≥98%
Description
Product Info
Shipping and Storage
Downloads
References

Description
This pentapeptide is equivalent to a sequence found on the B1 chain of laminin (929-933); it exhibits anticancer and anti-metastatic activities. Like other laminin peptide, this sequence can be used in combination with chemotherapeutics to deliver the drug to target tumor tissues. This peptide increases collagen type 1 synthesis in fibroblasts. In prostate cancer cells, this peptide decreases the mitochondrial membrane potential, inhibits ATP synthesis, and increases caspase 9 activity, inhibiting cell migration and growth.
Product Info
Cas No.
110590-64-2
Purity
≥98%
Formula
C
26
H
42
N
8
O
8
Formula Wt.
594.66
IUPAC Name
Tyrosylisoleucylglycylseryl-N5-(diaminomethylene)ornithine
Appearance
White to off white powder
Shipping and Storage
Store Temp
-20°C
Ship Temp
Ambient
Downloads
MSD
S
L0248
MSD
S PDF
Info Sheet
L0248 Info Sheet PDF
References
Yoon JH, Kim J, Lee H, et al. Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts. Biochem Biophys Res Commun. 2012 Nov 23;428(3):416-21. PMID: 23111328.
Dubey PK, Singodia D, Vyas SP. Polymeric nanospheres modified with YIGSR peptide for tumor targeting. Drug Deliv. 2010 Sep-Oct;17(7):541-51. PMID: 20560774.
Yu HN, Zhang LC, Yang JG, et al. Effect of laminin tyrosine-isoleucine-glycine-serine-arginine peptide on the growth of human prostate cancer (PC-3) cells in vitro. Eur J Pharmacol. 2009 Aug 15;616(1-3):251-5. PMID: 19577562.