商品编号


YIF-LF-MA0196



品牌


Adipogen



公司


Adipogen



公司分类


Antibodies



Size

100 ?l

商品信息


More Information



Product Details



Synonyms

TAB1; MAP3K7IP1; TAK1-binding Protein 1; TGF-β-activated Kinase 1-binding Protein 1; TGF-β-activated Kinase 1 and MAP3K7-binding Protein 1; Mitogen-activated Protein Kinase Kinase Kinase 7-interacting Protein 1



Product Type

Monoclonal Antibody



Properties



Clone

2D3



Isotype

Mouse IgG2a κ



Immunogen/Antigen

Recombinant human His-TAB1(1~300) protein purified from E. coli.



Application


ELISA
Western Blot (1:5,000~10,000)



Crossreactivity

Human
Mouse
Rat



Purity Detail

Ammonium sulfate precipitation.



Formulation

Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





TAK1 (transforming growth factor-β-activated kinase 1) is a MAPKKK activated by TGF-β, or the pro-inflammatory cytokines TNF (tumour necrosis factor) and IL-1 (interleukin-1), or bacterial LPS (lipopolysacchar-ide). It plays a key role in switching on several pro-inflammatory signaling pathways, including those that activate the MAPKs (mitogen-activated protein kinases), termed p38α MAPK, JNK1/2 (c-Jun N-terminal kinase 1/2) and ERK1/2 (extracellular-signal-regulated kinase 1/2), as well as the transcription factor NFκB (nuclear factor κB). TAB1 (TAK1-binding protein 1) is one of the regulatory subunits of TAK1 and plays a role as an activator of TAK1 in response to stimulation of ΤGF-β. TAB-1 can also mediate MKK-independent p38 kinase. Recently, induction of p38 autophosphorylation and consequent kinase activation by TAB1 expression in cultured neonatal cardiomyocytes have been reported. May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.


Product References
1) Sun P. et al., (2007) Cell. 128:295-308. (General)
2) New L. et al., (1998) EMBO J. 17:3372-3384. (General)