商品编号


YIF-LF-MA0344



品牌


Adipogen



公司


Adipogen



公司分类


Antibodies



Size

100 ?l

商品信息


More Information



Product Details



Synonyms

PTPT; TCPTP; PTPN2; EC=3.1.3.48; T-Cell Protein-Tyrosine Phosphatase; Tyrosine-Protein Phosphatase Non-Receptor Type 2



Product Type

Monoclonal Antibody



Properties



Clone

T25-AF3B7



Isotype

Mouse IgG2b κ



Immunogen/Antigen

Recombinant human protein purified from E. coli.



Application


ELISA
Western Blot (1:2,000)



Crossreactivity

Human



Purity Detail

Ammonium sulfate precipitation.



Formulation

Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by AbFrontier



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





T cell protein tyrosine phosphatase (TCPTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. TCPTP is ubiquitously expressed with particularly high expression in hematopoietic tissues and exists as two forms: an endoplasmic reticulum-targeted 48-kDa form (TC48) and a nuclear 45-kDa form (TC45). Although targeted to the nucleus, TC45 can exit in response to specific stimuli to dephosphorylate cytoplasmic substrates. TC-PTP is a negative regulator of the Jak/Stat cytokine signaling pathway. TCPTP is the PTP most closely related to PTP1B, with 72% sequence identity and 86% similarity in the catalytic domain.


Product References
1) Galic S et al., (2003) Mol Cell Biol 23(6):2096-108. (General)
2) Bourdeau A et al., (2007) Blood 109(10):4220-8. (General)
3) Doody KM et al., (2009) Immunol Rev 228(1):325-41. (General)