商品编号


JAI-MTG-100P



品牌


Adipogen



公司


Adipogen



公司分类


Antibodies



Size

100 ?g

商品信息


More Information



Product Details



Product Type

Monoclonal Antibody



Properties



Clone

2E8



Isotype

Mouse IgG1κ



Immunogen/Antigen

Thymidine glycol polymer.



Application


Immunohistochemistry:
Recommended concentration is 5-10μg/mL




Crossreactivity

All
Human



Specificity

Recognizes DNA containing thymidine glycol. Does not cross-react with oxidized dC polymer, oxidized dG polymer and oxidized dA polymer. Does not react with free thymidine glycol.



Formulation

Lyophilized. Contains 10mM PBS, pH7.4 containing 1.0% BSA.



Reconstitution

Reconstitute with 1mL distilled water.



Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.



Declaration

Manufactured by JaICA.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 3 years after receipt when stored at -20°C.
After reconstitution, prepare aliquots and store at -20°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





Thymidineglycol (TG) is one of the major oxidation products of DNA. Thymidine (T) can be damaged by oxidative stress such as r
ADI
ation and energy metabolism. Two different pathways to form TG have been suggested. Deoxythymidine in DNA is directly oxidised by hydroxy r
ADI
cal, to form TG. TG can be also formed through an intermediate thymidine chlorohydrin, which is derived from hypochlorous acid (HOCl) from neutrophil myeloperoxidase. Thymidineglycol is derived from DNA, not from RNA. TG is the oxidative stress
Marker
secific for DNA damage. In comparison with 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is the best known DNA oxidation product it was shown that in a lipopolysaccharide (LPS)-treated mouse liver, 8-OHdG can be stained within 24 hours after LPS treatment. TG can be detected within 6 hours, and remains at least for 72 hours.


Product References

Serum antioxidant capacity and oxidative injury to pulmonary DNA in never-smokers with primary lung cancer: K. Ito, et al.; Anticancer Res.
32,
1063 (2012)