商品编号


AG-20T-0307-C100



品牌


Adipogen



公司


Adipogen



公司分类


Antibodies



Size

100 ?g

商品信息


More Information



Product Details



Synonyms

Toll-like Receptor 8; CD288



Product Type

Monoclonal Antibody



Properties



Clone

ABM15F6



Isotype

Mouse IgG1κ



Immunogen/Antigen

Recombinant human TLR8 protein (aa 750-900).



Application


Flow Cytometry:
(0.5-2μg/10
6
cells)
Immunohistochemistry:
(5μg/ml; paraffin sections)
Optimal conditions must be determined individually for each application.



Crossreactivity

Human



Specificity

Recognizes human TLR8.



Purity

Protein G purified.



Concentration

0.5mg/ml



Formulation

Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.



Declaration

Q9NR97



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.
Stable for at least 6 months after receipt when stored at +4°C.



Documents



MSD
S

No



Product Specification Sheet



Datasheet


Download PDF





TLR8 (Toll-like Receptor 8) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR8 is a nucleotide-sensing TLR. TLR8 and TLR7 recognize single-stranded RNA (ssRNA) sequences containing GU-rich or poly-U sequences as their natural ligands, and they are also activated by synthetic small-molecular-weight compounds of the imidazoquinoline family. Both TLR8 and TLR7 signal via MYD88 and TRAF6, le
ADI
ng to NF-κB and antiviral factor, such as IRF family activation, cytokine secretion and the inflammatory response. They are localized intracellularly to endosomal membranes and act as potent activators of innate immune responses upon viral infection. The TLR8 gene is predominantly expressed in lung and peripheral blood leukocytes and lies in close proximity to TLR7 on chromosome X. Genetic variants in TLR8 have been linked to susceptibility to pulmonary tuberculosis. Recently, small molecule TLR7/8 ago
NIST
s have demonstrated potential as vaccine adjuvants, since they directly activate antigen-presenting cells (APCs) and can enhance both humoral and cellular immune responses, especially Th1 responses. This makes the TLR7/8 signaling pathways interesting therapeutic targets.