商品编号


AG-25B-0011-R050



品牌


Adipogen



公司


Adipogen



公司分类


Antibodies



Size

50 ?l


商品信息


More Information



Product Details



Synonyms

TRIF-related Adapter Molecule; TIRP; Toll-Interleukin 1 Receptor [TIR] Domain-containing Protein; TICAM-2; TIR-containing Adapter Molecule-2



Product Type

Polyclonal Antibody



Properties



Source/Host

Rabbit



Immunogen/Antigen

Synthetic peptide corresponding to aa 2-29 (G
2
IGKSKINSCPLSLSWGKRHSVDTSPGY
29
) of human TRAM.



Application


Western Blot
: (1:1'000)



Crossreactivity

Human



Specificity

Recognizes human TRAM.



Formulation

Liquid. Neat serum containing 0.02% sodium azide.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



MSD
S


Download PDF



Product Specification Sheet



Datasheet


Download PDF





TRAM functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. It is also involved in IL-1-triggered NF-κB activation, functioning upstream of IRAK1, IRAK2, TRAF6 and IKBKB. TRAM physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TRL4 signal to TICAM-1. It is expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle and pancreas.


Product References

Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells: E. Aksoy, et al.; Blood
109,
2887 (2007)?