商品编号


AG-25B-0008-C050



品牌


Adipogen



公司


Adipogen



公司分类


Antibodies



Size

50 ?g


商品信息


More Information



Product Details



Synonyms

Toll-interleukin-1 Receptor [TIR] Domain-containing Adapter Inducing Interferon-β; TICAM-1; TIR-containing Adaptor Molecule-1



Product Type

Polyclonal Antibody



Properties



Source/Host

Rabbit



Immunogen/Antigen

Synthetic peptide corresponding to aa 4-31 (T
4
GPSLPSAFDILGAAGQDKLLYLKHKLK
31
) of N-terminal human TRIF.



Application


Immunoprecipitation
Western Blot:
(1:1'000)



Crossreactivity

Human



Specificity

Recognizes human TRIF.



Purity Detail

Protein A-affinity purified.



Concentration

1 mg/ml



Formulation

Liquid. In PBS containing 0.02% sodium azide.



Shipping and Handling



Shipping

BLUE ICE



Short Term Storage

+4°C



Long Term Storage

-20°C



Handling Advice

Avoid freeze/thaw cycles.



Use/St
ABI
lity

Stable for at least 1 year after receipt when stored at -20°C.



Documents



MSD
S


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Product Specification Sheet



Datasheet


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TRIF is involved in innate immunity against inv
ADI
ng pathogens. It is an adaptor used by TLR3 and TLR4 (through TICAM-2) to mediate NF-κB and interferon-regulatory factor (IRF) activation and to induce apoptosis. Ligand binding to TLR3 and TLR4 results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-κB and FADD respectively. TRIF is ubiquitously expressed with higher levels in liver.


Product References

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling: M. Carty, et al.; Nat. Immunol.
7,
1074 (2006)?

Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells: E. Aksoy, et al.; Blood
109,
2887 (2007)?

The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases: M. Rebsamen, et al.; Cell Death Differ.
15,
1804 (2008)