商品编号


F5100



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

5 mg

商品信息

PYR-41 is a cell-permeable, irrevers
IBL
e ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10="" μm).="" treatment="" of="" cells="" with="" pyr-41="" inhibits="" overall="" protein="" ubiquitination,="" prevents="" ubiquitin-mediated="" proteasomal="" degradation,="" and="" inhibits="" pathways="" mediated="" by="" the="" ubiquitin-proteasome.="" it="" has="" also="" been="" found="" that="" pyr-41="" treatment="" increases="" protein="" sumoylation="" in="">

Additional Information






Product Name:

PYR-41



Also Known As:

4[4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester



Catalog No.:

F5100



Size:

5 mg



Molecular Weight:

371.3 Da



Species:

N/A



Source:

Synthetic



Stock:

Powder



Concentration:

N/A



Quality Assurance:

> 98% (TLC); NMR (Confirms)



Storage:

Elig
IBL
e for room temperature shipping. Store at -20°C upon receiving; protect from air and light



PDF Data Sheet:

PDF Datasheet



NCBI RefSeq:

N/A



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

Yang, Y.,
et al
. (2007) Cancer Res. 67: 9472.




Details

PYR-41 is a cell-permeable, irrevers
IBL
e ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10="" μm).="" treatment="" of="" cells="" with="" pyr-41="" inhibits="" overall="" protein="" ubiquitination,="" prevents="" ubiquitin-mediated="" proteasomal="" degradation,="" and="" inhibits="" pathways="" mediated="" by="" the="" ubiquitin-proteasome.="" it="" has="" also="" been="" found="" that="" pyr-41="" treatment="" increases="" protein="" sumoylation="" in="" cells.="">