商品编号


F7121



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

25 mg

商品信息

VX-765 is an orally absorbed prodrug of VRT-043198, a potent and selective inhibitor of caspase-1 and 4. In cultures of peripheral blood mononuclear cells stimulated with bacterial products, VRT-043198 inhibited the release of Interleukin (IL)-1β and IL-18, but had no affect the secretion of other cytokines including IL-α, TNFα, IL-6 and IL-8

Additional Information






Product Name:

VX-765



Also Known As:

N/A



Catalog No.:

F7121



Size:

25 mg



CAS:

273404-37-8



Formula:

C
24
H
33
ClN
4
O
6
?



Molecular Weight:

509 Da



Form:

Lyophilized powder



Quality Assurance:

>98% by HPLC and NMR



Source:

Synthetic



Storage:

Elig
IBL
e for room temperature shipping. Store at 2-8°C upon receiving



PDF Data Sheet:

Download PDF datasheet



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

1. Wannamaker W,
et al
. (2007) J Pharmacol Exp Ther 2007,321:509-516.
2. Doitsh G,
et al
. (2014) Nature 2014,505:509-514.




Details

VX-765 is an orally absorbed prodrug of VRT-043198, a potent and selective inhibitor of caspase-1 and 4. In cultures of peripheral blood mononuclear cells stimulated with bacterial products, VRT-043198 inhibited the release of Interleukin (IL)-1β and IL-18, but had no affect the secretion of other cytokines including IL-α, TNFα, IL-6 and IL-8