商品编号


F8110



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

5 mg

商品信息

Doxorubicin is an anthracycline antitumor antibiotic that Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Doxorubicin binds covalently to DNA and inhbibits reverse transcriptase, RNA polymerase and the catalytic activity of Dnmt1.


Additional Information






Product Name:

Doxorubicin HCl



Also Known As:

10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride



Catalog No.:

F8110



Size:

5 mg



Molecular Weight:

579.99 Da



Species:

N/A



Source:

Synthetic



Stock:

Powder



Concentration:

N/A



Quality Assurance:

>99% by HPLC and NMR



Storage:

Elig
IBL
e for room temperature shipping. Store at -20°C upon receiving; protect from air and light



PDF Data Sheet:

PDF Datasheet



NCBI RefSeq:

N/A



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

1. T
AAT
jes DJ,
et al
(1996) J. Med. Chem. 39: 4135-4138.
2. Pourquier P,
et al
. (1998) Biochem. Pharmacol. 55: 1963-1971.
3. Zeman SM,
et al
. (1998) Proc. Natl. Acad. Sci. U.S.A. 95: 11561-11565.
4. Sun W,
et al
. (2009 ) Cancer Res. 69(10): 4294-4300.
5. Granados-Principal S,
et al
. (2010) Food Chem Toxicol 48(6): 1425-1438.




Details

Doxorubicin is an anthracycline antitumor antibiotic that Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Doxorubicin binds covalently to DNA and inhbibits reverse transcriptase, RNA polymerase and the catalytic activity of Dnmt1.

How to use
Doxorubicin hydrochloride was used at 1-1,000 nM in various cell-based assays.