商品编号


F8130



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


Inhibitors



Size

5 mg

商品信息

VE-821 is a potent and selective ATP competitive inhibitor of ataxia-telangiectasia and Rad3-related protein (ATR) with IC50 of 26 nM in cell-free assays, with minimal activity against ATM, DNA-PK, and mTOR. It augments DNA damage and cell death of cancer cells in response to r
ADI
ation, also sensitizes cancer cells to chemotherapy.

Additional Information






Product Name:

VE-821



Also Known As:

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide



Catalog No.:

F8130



Size:

5 mg



CAS:

1232410-49-9



Formula:

C
18
H
16
N
4
O
3
S



Molecular Weight:

368.41 Da



Form:

Lyophilized powder



Quality Assurance:

>98% by HPLC and NMR



Source:

Synthetic



Storage:

Elig
IBL
e for room temperature shipping. Store at -80°C upon receiving



PDF Data Sheet:

Download PDF datasheet



Image(s):

N/A



Shipping Method:

Room temperature shipping



References:

1. Reaper PM,
et al
. (2011) Nat Chem Biol, 7(7), 428-430.
2. Prevo, R,
et al
. (2012) Cancer Biol Ther, 13(11) 1072-1081.
3. Huntoon, CJ,
et al
. (2013) Cancer Res, 73(12) 3683-3691.




Details

VE-821 is a potent and selective ATP competitive inhibitor of ataxia-telangiectasia and Rad3-related protein (ATR) with IC50 of 26 nM in cell-free assays, with minimal activity against ATM, DNA-PK, and mTOR. It augments DNA damage and cell death of cancer cells in response to r
ADI
ation, also sensitizes cancer cells to chemotherapy.

Solubility:

20 mg/ml in DMSO