商品编号


6326/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

50 mg

商品信息

Description:
Inhibits SUMOylation by binding E1

Chemical Name:
2-Hydroxy-6-(8
Z
)-8-pentadecenylbenzoic acid

Purity:
≥97% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Inhibitor of SUMOylation (IC
50
= 3 μM). Directly binds E1 and inhibits formation of E1-SUMO intermediate. Protects against amyloid β-induced impairment of neurotransmission and synaptic plasticity. Also suppresses CD44 and MMP14 expression in breast cancer cells, eliminating cancer stem cells and inhibiting tum
Origen
esis.



Technical Data



M. Wt

346.5



Formula

C
22
H
34
O
3




Storage

Store at -20°C



Purity

≥97% (HPLC)



CAS Number

22910-60-7



PubChem ID

5281858



InChI Key

YXHVCZZLWZYHSA-FPLPWBNLSA-N



Smiles

CCCCCC/C=CCCCCCCCC1=C(C(O)=CC=C1)C(O)=O



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

34.65

100



ethanol

34.65

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
346.5
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.89 mL

14.43 mL

28.86 mL



5 mM

0.58 mL

2.89 mL

5.77 mL



10 mM

0.29 mL

1.44 mL

2.89 mL



50 mM

0.06 mL

0.29 mL

0.58 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Fukuda

et al
(2009) Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem.Biol.
16
133 PMID: 19246003


Mango

et al
(2016) Ginkgolic acid protects against Aβ-induced synaptic dysfunction in the hippocampus. Front.Pharmacol.
7
401 PMID: 27833555


Bogachek

et al
(2016) Inhibiting the SUMO pathway represses the cancer stem cell population in breast and colorectal carcinomas. Stem Cell Reports.
7
1140 PMID: 27916539




Keywords: Ginkgolic Acid, supplier, inhibitors, inhibits, SUMOylation, ubiquitin, activating, enzyme, E1, neuroprotective, CD44, Other, Ligases, Post-translational, Modifications, Cancer, Stem, Cells, Other, Ligases,
Tocris
Bioscience