商品编号


3503/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

10 mg

商品信息

Description:
Hdm2 inhibitor; activates p53-dependent transcription

Chemical Name:
5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-
b
]quinoline-2,4(3
H
,10
H
)-dione dihydrochloride

Purity:
≥99% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.



Technical Data



M. Wt

414.33



Formula

C
18
H
23
N
5
O
2
.2HCl



Storage

Desiccate at RT



Purity

≥99% (HPLC)



CAS Number

502137-98-6



PubChem ID

72193867



InChI Key

WUEMKAQTAIRDOA-UHFFFAOYSA-N



Smiles

CN2C1=CC=CC=C1C(NCCCN(C)C)=C3C2=NC(N(C)C3=O)=O.Cl.Cl



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

3.78

10



water

37.79

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
414.33
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.41 mL

12.07 mL

24.14 mL



5 mM

0.48 mL

2.41 mL

4.83 mL



10 mM

0.24 mL

1.21 mL

2.41 mL



50 mM

0.05 mL

0.24 mL

0.48 mL






Molarity Calculator






Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.











Reconstitution Calculator






Reconstitution Calculator









Dilution Calculator






Dilution Calculator

Calculate the dilution required to prepare a stock solution.













Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

Select another language:



English
German
French
Spanish

View SDS





References

References are publications that support the products'
BIOLOG
ical activity.


Kitagaki

et al
(2008) Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol.Cancer Ther.
7
2445 PMID: 18723490


Yang

et al
(2009) Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci.
100
24 PMID: 19037995




Keywords: HLI 373, supplier, Hdm2, inhibitors, inhibits, inhibitor, p53, transcription, activators, HLI373, p53, Ubiquitin, E3, Ligases, Ubiquitin, E3, Ligases,
Tocris
Bioscience