商品编号


2192/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Polymerases



Size

50 mg

商品信息

Description:
PARP inhibitor

Chemical Name:
4-(1
H
)-Quinazolinone

Purity:
≥99% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC
50
= 9.5
μ
M); displays mixed inhibition with respect to NAD
+
. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice
in vivo
; decreases NF-
κ
B and AP-1 activation.



Technical Data



M. Wt

146.15



Formula

C
8
H
6
N
2
O



Storage

Desiccate at RT



Purity

≥99% (HPLC)



CAS Number

491-36-1



PubChem ID

63112



InChI Key

QMNUDYFKZYBWQX-UHFFFAOYSA-N



Smiles

OC1=C2C=CC=CC2=NC=N1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

14.62

100



water

1.46

10





Preparing Stock Solutions

The following data is based on the
product
molecular weight
146.15
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

6.84 mL

34.21 mL

68.42 mL



5 mM

1.37 mL

6.84 mL

13.68 mL



10 mM

0.68 mL

3.42 mL

6.84 mL



50 mM

0.14 mL

0.68 mL

1.37 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Banasik

et al
(1992) Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J.Biol.Chem.
267
1569 PMID: 1530940


Halmosi

et al
(2001) Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. Mol.Pharmacol.
59
1497 PMID: 11353811


Veres

et al
(2004) Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. J.Pharmacol.Exp.Ther.
310
247 PMID: 14999056




Keywords: 4-HQN, supplier, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerase, Polymerases, Poly(ADP-ribose), Polymerase, Poly(ADP-ribose), Polymerase,
Tocris
Bioscience