商品编号


5433/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

10 mg

商品信息

Description:
HECT E3 ubiquitin ligase inhibitor

Chemical Name:

N
-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

HECT E3 ubiquitin ligase inhibitor; inhibits Nedd4, Smurf2 and WWP1 (IC
50
values are 6.3, 6.8 and 6.9
μ
M respectively). Selective for HECT-mediated over RING-mediated ubiquitination.



Compound Libraries

Heclin is also offered as part of the
Tocris
creen Plus. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

283.32



Formula

C
17
H
17
NO
3




Storage

Store at -20°C



Purity

≥98% (HPLC)



CAS Number

890605-54-6



PubChem ID

7464118



InChI Key

SPTWXRJNCFIDRQ-ZHACJKMWSA-N



Smiles

CC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

28.33

100



ethanol

14.17

50





Preparing Stock Solutions

The following data is based on the
product
molecular weight
283.32
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

3.53 mL

17.65 mL

35.3 mL



5 mM

0.71 mL

3.53 mL

7.06 mL



10 mM

0.35 mL

1.76 mL

3.53 mL



50 mM

0.07 mL

0.35 mL

0.71 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Mund

et al
(2014) Peptide and small molecule inhibitors of HECT-type ubiquitin ligases. Proc.Natl.Acad.Sci.U.S.A.
111
16736 PMID: 25385595




Keywords: Heclin, supplier, E6-AP, carboxyl, terminus, HECT, E3, ubiquitin, ubiquitination, inhibitors, inhibits, inhibts, NAMs, negative, allosteric, modulators, Ubiquitin, E3, Ligases, Ubiquitin, E3, Ligases,
Tocris
Bioscience