商品编号


3561/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

50 mg

商品信息

Description:
DNA ligase I, III and IV inhibitor

Chemical Name:
6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1
H
)-pyrimidineone


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

DNA ligase I, III and IV inhibitor (IC
50
values are 5, 9 and 5
μ
M respectively) that blocks DNA binding (K
i
= 5
μ
M for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.



Technical Data



M. Wt

246.29



Formula

C
11
H
10
N
4
OS



Storage

Store at -20°C



CAS Number

64232-83-3



PubChem ID

824710



InChI Key

SAKOXVNKDMWWLF-UHFFFAOYSA-N



Smiles

S=C1NC(N)=C(/N=C/C2=CC=CC=C2)C(N1)=O



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

24.63

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
246.29
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

4.06 mL

20.3 mL

40.6 mL



5 mM

0.81 mL

4.06 mL

8.12 mL



10 mM

0.41 mL

2.03 mL

4.06 mL



50 mM

0.08 mL

0.41 mL

0.81 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Chen

et al
(2008) Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res.
68
3169 PMID: 18451142




Keywords: L189, supplier, DNA, ligases, I, III, IV, 1, 3, 4, inhibitors, inhibits, DNA, Ligases, DNA, Ligases,
Tocris
Bioscience