商品编号


5084/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Polymerases



Size

50 mg

商品信息

Description:
Potent and selective tankyrase inhibitor

Chemical Name:
2-[4-(1-Methylethyl)phenyl]-4
H
-1-benzopyran-4-one

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Potent and selective tankyrase (TNKS) inhibitor (IC
50
values are 6 and 72 nM for TNKS1 and TNKS2 respectively). Has no significant effect on PARP-1 or PARP-2 (IC
50
>19
μ
M). Inhibits WNT/
β
-catenin signaling-dependent Super-TopFlash (STF) luciferase activity.



Technical Data



M. Wt

264.32



Formula

C
18
H
16
O
2




Storage

Store at +4°C



Purity

≥98% (HPLC)



CAS Number

92831-11-3



PubChem ID

2802462



InChI Key

PYTOHIUBXSJKQH-UHFFFAOYSA-N



Smiles

O=C2C1=CC=CC=C1OC(C3=CC=C(C(C)C)C=C3)=C2



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

26.43

100



ethanol

26.43

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
264.32
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

3.78 mL

18.92 mL

37.83 mL



5 mM

0.76 mL

3.78 mL

7.57 mL



10 mM

0.38 mL

1.89 mL

3.78 mL



50 mM

0.08 mL

0.38 mL

0.76 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Narwal

et al
(2013) Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem.
56
7880 PMID: 24116873




Keywords: MN 64, supplier, MN64, potent, selective, tankyrase, inhibitors, TNKS, TNKS1, TNKS2, WNT, inhibits, Poly(ADP-ribose), Polymerase, Tankyrase, Tankyrase,
Tocris
Bioscience