商品编号


4993/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

10 mg

商品信息

Description:
Ubiquitin-activating enzyme (E1) inhibitor

Chemical Name:

N
-[2-[[(4-Chlorophenyl)methyl]dithio]ethyl]-1-decanamine hydrochloride

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Ubiquitin-activating enzyme (E1) inhibitor; prevents tumour suppressor protein p27 ubiquitination
in vitro
. Blocks the ubiquitin-thioester formation step of the E1 activation reaction, but displays no effect on ubiquitin adenylation.



Technical Data



M. Wt

410.51



Formula

C
19
H
32
ClNS
2
.HCl



Storage

Store at -20°C



Purity

≥98% (HPLC)



CAS Number

13116-77-3



PubChem ID

361263



InChI Key

JQHUAYXPNPTQRO-UHFFFAOYSA-N



Smiles

ClC1=CC=C(CSSCCNCCCCCCCCCC)C=C1.Cl



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

20.53

50



ethanol

8.21

20





Preparing Stock Solutions

The following data is based on the
product
molecular weight
410.51
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.44 mL

12.18 mL

24.36 mL



5 mM

0.49 mL

2.44 mL

4.87 mL



10 mM

0.24 mL

1.22 mL

2.44 mL



50 mM

0.05 mL

0.24 mL

0.49 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Ungermannova

et al
(2012) Identification and mecha
NIST
ic studies of a novel ubiquitin E1 inhibitor. J.Biomol.Screen.
17
421 PMID: 22274912




Keywords: NSC 624206, supplier, NSC624206, tumour, suppressor, protein, p27, ubiquitination, thioesterformation, adenylation, ubiquitin-activating, enzymes, E1, inhibitors, inhibits, Ubiquitin-activating, Enzyme, E1, Post-translational, Modifications, Ubiquitin-activating, Enzyme, E1,
Tocris
Bioscience