商品编号


1401/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Polymerases



Size

10 mg

商品信息

Description:
Potent PARP inhibitor

Chemical Name:
8-Hydroxy-2-methyl-4(3
H
)-quinazolinone

Purity:
≥99% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K
i
and IC
50
values are 48 and 400 nM respectively.



Compound Libraries

NU 1025 is also offered as part of the
Tocris
creen Plus. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

176.17



Formula

C
9
H
8
N
2
O
2




Storage

Store at RT



Purity

≥99% (HPLC)



CAS Number

90417-38-2



PubChem ID

63306



InChI Key

YJDAOHJWLUNFLX-UHFFFAOYSA-N



Smiles

CC1=NC2=C(O)C=CC=C2C(=O)N1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



1eq. HCl

17.62

100



1eq. NaOH

17.62

100



DMSO

17.62

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
176.17
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

5.68 mL

28.38 mL

56.76 mL



5 mM

1.14 mL

5.68 mL

11.35 mL



10 mM

0.57 mL

2.84 mL

5.68 mL



50 mM

0.11 mL

0.57 mL

1.14 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Bowman

et al
(1998) Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br.J.Cancer.
78
1269 PMID: 9823965


Delaney

et al
(2000) Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin.Cancer.Res.
6
2860 PMID: 10914735


Griffin

et al
(1998) Resistance-modifying agents. 5. Synthesis and
BIOLOG
ical properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). J.Med.Chem.
41
5247 PMID: 9857092




Keywords: NU 1025, supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerases, NU1025, Poly(ADP-ribose), Polymerase, Poly(ADP-ribose), Polymerase,
Tocris
Bioscience