商品编号


4106/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Polymerases



Size

50 mg

商品信息

Description:
PARP-1 inhibitor

Chemical Name:
Pyridine-3-carboxamide

Purity:
≥99% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Anti-inflammatory agent. Inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. NAD
+
precursor. Promotes differentiation of mesenchymal stem cells to insulin producing cells when used in combination with growth factors and high glucose concentration.



Compound Libraries

Nicotinamide is also offered as part of the
Tocris
creen Stem Cell Toolbox. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

122.12



Formula

C
6
H
6
N
2
O



Storage

Store at RT



Purity

≥99% (HPLC)



CAS Number

98-92-0



PubChem ID

936



InChI Key

DFPAKSUCGF
BD
DF-UHFFFAOYSA-N



Smiles

O=C(C1=CC=CN=C1)N



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

12.21

100



ethanol

12.21

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
122.12
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

8.19 mL

40.94 mL

81.89 mL



5 mM

1.64 mL

8.19 mL

16.38 mL



10 mM

0.82 mL

4.09 mL

8.19 mL



50 mM

0.16 mL

0.82 mL

1.64 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Suzuki

et al
(2010) Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake. Life.Sci.
86
676 PMID: 20188745


Cimadamore

et al
(2009) Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death. Stem Cells.
27
1772 PMID: 19544437


Czubak

et al
(2014) A modified method of insulin producing cells' generation from bone marrow-derived mesenchymal stem cells. J.Diabetes Res.
2014
628591 PMID: 25405207




Keywords: Nicotinamide, supplier, Nicotinamide, inhibits, poly(ADP-ribose), polymerase-1, PARP-1, inhibitors, anti-inflammatory, organoids, Poly(ADP-ribose), Polymerase, Mesenchymal, Stem, Cells, Poly(ADP-ribose), Polymerase,
Tocris
Bioscience