商品编号


3984/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

10 mg

商品信息

Description:
MDM2 antago
NIST
; inhibits MDM2-p53 interaction

Chemical Name:
(±)-4-[4,5-
Bis
(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

MDM2 antago
NIST
; inhibits the MDM2-p53 interaction (IC
50
= 0.09
μ
M) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.



Licensing Information

Sold under license from F. Hoffmann-La
Roche
Ltd.



Compound Libraries

Nutlin-3 is also offered as part of the
Tocris
creen Plus. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

581.49



Formula

C
30
H
30
Cl
2
N
4
O
4




Storage

Store at -20°C



Purity

≥98% (HPLC)



CAS Number

548472-68-0



PubChem ID

16755649



InChI Key


BD
UHCSBCVGXTJM-IZLXSDGUSA-N



Smiles

ClC1=CC=[C@@]([C@@H]3[C@@H](N(C(N5CC(NCC5)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N3)[C@]2=CC=C(Cl)C=C2)C=C1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

58.15

100



ethanol

58.15

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
581.49
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

1.72 mL

8.6 mL

17.2 mL



5 mM

0.34 mL

1.72 mL

3.44 mL



10 mM

0.17 mL

0.86 mL

1.72 mL



50 mM

0.03 mL

0.17 mL

0.34 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Vassilev

et al
(2004) In vivo activation of the p53 pathway by small-molecule antago
NIST
s of MDM2. Science
303
844 PMID: 14704432




Keywords: Nutlin-3, supplier, Nutlin3, p53, activator, MDM2, antago
NIST
, antago
NIST
s, p53-MDM2, p53, Ubiquitin, E3, Ligases, Ubiquitin, E3, Ligases,
Tocris
Bioscience