商品编号


5191/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

10 mg

商品信息

Description:
Bmi-1 inhibitor; antitumor

Chemical Name:

N
-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Bmi-1 inhibitor (IC
50
~ 0.5
μ
M); irrevers
IBL
y impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors
in vivo
.



Technical Data



M. Wt

495.19



Formula

C
17
H
13
Br
2
N
5
OS



Storage

Store at -20°C



Purity

≥98% (HPLC)



CAS Number

315704-66-6



PubChem ID

1117196



InChI Key

XVOOCQSWCCRVDY-UHFFFAOYSA-N



Smiles

CC3=C(N(C=CC=N4)C4=N3)C1=CSC(NC2=C(Br)C=C(OC)C=C2Br)=N1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

49.52

100



ethanol

9.9

20





Preparing Stock Solutions

The following data is based on the
product
molecular weight
495.19
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.02 mL

10.1 mL

20.19 mL



5 mM

0.4 mL

2.02 mL

4.04 mL



10 mM

0.2 mL

1.01 mL

2.02 mL



50 mM

0.04 mL

0.2 mL

0.4 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Kreso

et al
(2014) Self-renewal as a therapeutic target in human colorectal cancer. Nat.Med.
20
29 PMID: 24292392




Keywords: PTC 209, supplier, PTC209, Bmi-1, inhibitors, inhibits, colorectal, cancer-initiating, cell, CIC, growth, polycomb, repressive, complex, 1, PRC1, B, lymphoma, Mo-MLV, insertion, region, 1, homolog, Ubiquitin, E3, Ligases, Ubiquitin, E3, Ligases,
Tocris
Bioscience