商品编号


4994/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

50 mg

商品信息

Description:
Ubiquitin-activating enzyme (E1) inhibitor

Chemical Name:
1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Ubiquitin-activating enzyme (E1) inhibitor. Blocks degradation of p53 and cyclin D3. Inhibits NF-
κ
B activation and induces cell death associated with ER stress. Displays antitumor effects in a mouse model of leukemia.



Technical Data



M. Wt

351.67



Formula

C
14
H
7
ClFN
3
O
5




Storage

Store at -20°C



Purity

≥98% (HPLC)



CAS Number

423148-78-1



PubChem ID

60111983



InChI Key

MSYMKEYWUWVZQY-TWGQIWQCSA-N



Smiles

FC(C=C3)=C(Cl)C=C3N(C(/C1=CC2=CC=C([N+]([O-])=O)O2)=O)NC1=O



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

35.17

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
351.67
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.84 mL

14.22 mL

28.44 mL



5 mM

0.57 mL

2.84 mL

5.69 mL



10 mM

0.28 mL

1.42 mL

2.84 mL



50 mM

0.06 mL

0.28 mL

0.57 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Xu

et al
(2010) The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood
115
2251 PMID: 20075161




Keywords: PYZD 4409, supplier, PYZD4409, ubiquitin-activating, enzyme, E1, inhibitors, inhibits, ubiquitylation, ubiquitin, Ubiquitin-activating, Enzyme, E1, Post-translational, Modifications, Ubiquitin-activating, Enzyme, E1,
Tocris
Bioscience