商品编号


4817/10



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

10 mg

商品信息

Description:
Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest

Chemical Name:
2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Inhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G
1
/S cell cycle arrest in T47D cells and LNCaP cells; induces G
2
/M cell cycle arrest in MCF-7 cells.



Technical Data



M. Wt

465.34



Formula

C
18
H
13
BrN
2
O
4
S
2




Storage

Store at +4°C



Purity

≥98% (HPLC)



CAS Number

432001-69-9



PubChem ID

5733396



InChI Key

IYCJJVVXEHZJHE-CHHVJCJISA-N



Smiles

BrC1=CC=C(OCC(O)=O)C(/C=C2SC(N(CC3=CN=CC=C3)C2=O)=S)=C1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

4.65

10





Preparing Stock Solutions

The following data is based on the
product
molecular weight
465.34
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.15 mL

10.74 mL

21.49 mL



5 mM

0.43 mL

2.15 mL

4.3 mL



10 mM

0.21 mL

1.07 mL

2.15 mL



50 mM

0.04 mL

0.21 mL

0.43 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Rico-Bautista and Wolf
(2012) Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation. Chem.Biol.
19
1497 PMID: 23261592


Wu

et al
(2012) Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem.Biol.
19
1515 PMID: 23261596




Keywords: SKPin C1, supplier, SKPinC1, skp2, SCF, E3, ligases, p27, accumulation, cell, cycle, arrest, inhibits, inhibitors, antitumor, Ubiquitin, E3, Ligases, Cell, Cycle, Inhibitors, Ubiquitin, E3, Ligases,
Tocris
Bioscience