商品编号


5076/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

50 mg

商品信息

Description:
Selective Skp2 inhibitor; suppresses E3 ligase activity

Chemical Name:
3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4
H
-1-benzopyran-4-one

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination
in vivo
and
in vitro
. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.



Technical Data



M. Wt

420.52



Formula

C
24
H
24
N
2
O
3
S



Storage

Store at +4°C



Purity

≥98% (HPLC)



CAS Number

222716-34-9



PubChem ID

1286902



InChI Key

JKIXLEKBXHMXTN-UHFFFAOYSA-N



Smiles

OC(C(CC)=C2)=C(CN3CCCCC3)C1=C2C(C(C4=NC5=C(C=CC=C5)S4)=CO1)=O



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



1eq. HCl

8.41

20



DMSO

2.1

5mM with gentle warming





Preparing Stock Solutions

The following data is based on the
product
molecular weight
420.52
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

2.38 mL

11.89 mL

23.78 mL



5 mM

0.48 mL

2.38 mL

4.76 mL



10 mM

0.24 mL

1.19 mL

2.38 mL



50 mM

0.05 mL

0.24 mL

0.48 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Chan

et al
(2013) Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell
154
556 PMID: 23911321




Keywords: SZL P1-41, supplier, SZLP1-41, Selective, Skp2, inhibitors, inhibits, suppresses, E3, ligase, SCF, complexes, antitumor, p27, Akt, ubiquitination, cell, senescence, glycolysis, Ubiquitin, E3, Ligases, Ubiquitin, E3, Ligases,
Tocris
Bioscience