商品编号


4855/50



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Polymerases



Size

50 mg

商品信息

Description:
Potent tankyrase inhibitor

Chemical Name:
2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4
H
-1,2,4-triazol-3-yl]thio]propyl]-1
H
-benz[
de
]isoquinoline-1,3(2
H
)-dione

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Inhibitor of Wnt/
β
-catenin signaling (EC
50
~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC
50
~15 nM); prevents the ubiquitination and degradation of axin.



Compound Libraries

WIKI4 is also offered as part of the
Tocris
creen Stem Cell Toolbox. Find out more about compound libraries available from
Tocris
.



Technical Data



M. Wt

521.59



Formula

C
29
H
23
N
5
O
3
S



Storage

Store at -20°C



Purity

≥98% (HPLC)



CAS Number

838818-26-1



PubChem ID

2984337



InChI Key

RNUXIZKXJOGYQP-UHFFFAOYSA-N



Smiles

O=C(C5=C4C(C6=O)=CC=CC4=CC=C5)N6CCCSC1=NN=C(C3=CC=NC=C3)N1C2=CC=C(OC)C=C2



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

10.43

20





Preparing Stock Solutions

The following data is based on the
product
molecular weight
521.59
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

1.92 mL

9.59 mL

19.17 mL



5 mM

0.38 mL

1.92 mL

3.83 mL



10 mM

0.19 mL

0.96 mL

1.92 mL



50 mM

0.04 mL

0.19 mL

0.38 mL






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


James

et al
(2012) WIKI4, a novel inhibitor of tankyrase and Wnt/
β
-catenin signaling. PLoS One
7
e50457 PMID: 23227175




Keywords: WIKI4, supplier, Wnt, signaling, signalling, inhibitors, inhibits, b-catenin, beta-catenin, β-catenin, tankyrase, TNKS2, Poly(ADP-ribose), Polymerase, Stem, Cell, Signaling, Tankyrase, Tankyrase,
Tocris
Bioscience