商品编号


6230



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Polymerases



Size

10 mg

商品信息

Description:
PARP inhibitor

Alternative Names:
CO-338

Chemical Name:
8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6
H
-pyrrolo[4,3,2,
ef
][2]benzazepin-6-one (1
S
,4
R
)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

PARP inhibitor. Chemosensitizes colorectal cancer cells to temozolomide (Cat.No. 2706) and topotecan (Cat.No. 4562)
in vitro
and
in vivo
.



Licensing Information

Sold for research purposes under agreement from Pfizer Inc.



Technical Data



M. Wt

555.66



Formula

C
19
H
18
FN
3
O.C
10
H
16
O
4
S



Storage

Store at -20°C



Purity

≥98% (HPLC)



CAS Number

1327258-57-0



PubChem ID

53356947



InChI Key

INBJJAFXHQQSRW-FHIDHQGESA-N



Smiles

CNCC1=CC=C(C2=C3CCNC(C4=C3C(N2)=CC(F)=C4)=O)C=C1.O=S(C[C@@]5(C6(C)C)CC[C@@H]6CC5=O)(O)=O



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

55.57

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
555.66
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

1.8 mL

9 mL

18 mL



5 mM

0.36 mL

1.8 mL

3.6 mL



10 mM

0.18 mL

0.9 mL

1.8 mL



50 mM

0.04 mL

0.18 mL

0.36 mL






Molarity Calculator






Molarity Calculator

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Reconstitution Calculator






Reconstitution Calculator



The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.



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ul



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Mass (in vial)




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ug
ng



÷


Desired Reconstitution Concentration




mg/ml
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ng/ml













Dilution Calculator






Dilution Calculator

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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Thomas

et al
(2007) Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol.Cancer Ther.
6
945 PMID: 17363489




Keywords: Rucaparib camsylate, supplier, PARP, inhibitors, inhibits, Poly(ADP-ribose), Polymerase, chemosentizers, chemosensitizes, CO-338, Poly(ADP-ribose), Polymerase,
Tocris
Bioscience