商品编号


6305



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Ligases



Size

100 mg

商品信息

Description:
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Chemical Name:
3-(4-Amino-1,3-dihydro-1-oxo-2
H
-isoindol-2-yl)-2,6-piperidinedione

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Thalidomide analog. Immune modulatory drug and cereblon binding compound. Induces ubiquitination and degradation of casein kinase (CK) 1α by the E3 ubiquitin ligase CRL4
CRBN
. Also TNF-α inhibitor and angiogenesis inhibitor.



Technical Data



M. Wt

259.26



Formula

C
13
H
13
N
3
O
3




Storage

Store at -20°C



Purity

≥98% (HPLC)



CAS Number

191732-72-6



PubChem ID

216326



InChI Key

GOTYRUGSSMKFNF-UHFFFAOYSA-N



Smiles

NC1=C2CN(C(C2=CC=C1)=O)C3CCC(NC3=O)=O



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

25.93

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
259.26
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

3.86 mL

19.29 mL

38.57 mL



5 mM

0.77 mL

3.86 mL

7.71 mL



10 mM

0.39 mL

1.93 mL

3.86 mL



50 mM

0.08 mL

0.39 mL

0.77 mL






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Reconstitution Calculator



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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Petzold

et al
(2016) Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase. Nature
532
127 PMID: 26909574


Kr?nke

et al
(2015) Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature
523
183 PMID: 26131937




Keywords: Lenalidomide, supplier, tumor, necrosis, factor, 1α, alpha, TNF, angiogenesis, inhibitor, cereblon, binder, ubiquitin, E3, ligase, Ubiquitin, E3, Ligases,
Tocris
Bioscience