商品编号


6234



品牌


Tocris



公司


Bio-Techne Corporation



公司分类


Polymerases



Size

10 mg

商品信息

Description:
Potent and selective hepatitis B virus inhibitor

Alternative Names:
BMS 200475, SQ 34676

Chemical Name:
2-Amino-1,9-dihydro-9-[(1
S
,3
R
,4
S
)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6
H
-purin-6-one

Purity:
≥98% (HPLC)


BIOLOG
ical Activity Technical Data Solubility Calculators Datasheets References


BIOLOG
ical Activity

Potent and selective hepatitis B virus reverse transcriptase inhibitor (EC
50
= 3 nM); guanine analog. Inhibits hepatitis B virus replication in HepG2.2.15 cells. Displays selectively over HCMV, HSV-1, VZV, HIV and influenza (EC
50
values are 15, 32, 30-60, >10 and >80
μ
M respectively). Orally bioavailable.



Technical Data



M. Wt

277.28



Formula

C
12
H
15
N
5
O
3




Storage

Store at -20°C



Purity

≥98% (HPLC)



CAS Number

142217-69-4



PubChem ID

153941



InChI Key

QDGZDCVAUDNJFG-FXQIFTODSA-N



Smiles

O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)C3=C)C=N2)NC(N)=N1



The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All
Tocris
products are intended for laboratory research use only.



Solubility Data




Solvent

Max Conc. mg/mL

Max Conc. mM



Solubility



DMSO

27.73

100





Preparing Stock Solutions

The following data is based on the
product
molecular weight
277.28
. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.



Concentration / Solvent Volume / Mass

1 mg

5 mg

10 mg



1 mM

3.61 mL

18.03 mL

36.06 mL



5 mM

0.72 mL

3.61 mL

7.21 mL



10 mM

0.36 mL

1.8 mL

3.61 mL



50 mM

0.07 mL

0.36 mL

0.72 mL






Molarity Calculator






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Reconstitution Calculator






Reconstitution Calculator



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Dilution Calculator






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Product Datasheets


Certificate of Analysis / Product Datasheet


Safety Datasheet

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References

References are publications that support the products'
BIOLOG
ical activity.


Innaimo

et al
(1997) Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus. Antimicrob. Agents Chemother.
41
1444 PMID: 9210663


Bisacchi

et al
(1997) BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity
in vitro
Bioorganic & Medicinal Chemistry Letters
7
127 PMID:




Keywords: Entecavir, supplier, Potent, selective, hepatitis, B, virus, inhibitors, HBV, inhibits, orally, bioavailable, BMS200475, SQ34676, nucleoside, reverse, transcriptase, NRTI, BMS, 200475, SQ, 34676, RNA/DNA, Polymerase,
Tocris
Bioscience