商品编号


K1300



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


E3 Ubiquitin Ligases



Size

25 ?g

商品信息

HSP70 a critical chaperone protein that has a high affinity for unfolded polypeptide chains. It binds extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In cooperation with other chaperones, Hsp70 st
ABI
lizes preexistent proteins against aggregation and mediates the folding of newly translated polypeptides in the cytosol as well as within organelles. Hsp70 and Hsp40 recruit some misfolded proteins to the ubiquitin E3 ligase CHIP for ubiquitination.



Additional Information






Product Name:

HSP70



Also Known As:

HSPA1A; HSP72; HSPA1; HSP70I; HSP70-1; HSP70-1A



Catalog No.:

K1300



Size:

25 ?g



Molecular Weight:

70 kDa



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~90% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet
，
MSD
S



NCBI RefSeq:

NM_005345



Image(s):

N/A



Shipping Method:

Dry ice shipping



References:

1. Walerych .,
et al
. (2009) Oncogene 28: 4284-94
2. Daugaard M,
et al
. (2007) FEBS Lett. 581: 3702-3710 3. Klucken J,
et al
.(2006) FASEB J. 20, 2050
4. Freeman BC,
et al
. (1995) EMBO J 14: 2281-22-92




Details

HSP70 a critical chaperone protein that has a high affinity for unfolded polypeptide chains. It binds extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In cooperation with other chaperones, Hsp70 st
ABI
lizes preexistent proteins against aggregation and mediates the folding of newly translated polypeptides in the cytosol as well as within organelles. Hsp70 and Hsp40 recruit some misfolded proteins to the ubiquitin E3 ligase CHIP for ubiquitination.