商品编号


K1420



品牌


UBPBio



公司


Ubiquitin-Proteasome Biotechnologies, LLC



公司分类


E3 Ubiquitin Ligases



Size

50 ?g


商品信息

NEDD4 (neural precursor cell expressed developmentally down-regulated protein 4) is a widely expressed HECT domain-containing E3 ubiquitin ligase. NEDD4 ubiquitinates a few membrane proteins, including IGF-1R and PTEN, by which it regulates signal transduction.




Additional Information






Product Name:

GST-NEDD4



Also Known As:

NEDD4-1; neural precursor cell expressed developmentally down-regulated protein 4



Catalog No.:

K1420



Size:

50 ?g



Molecular Weight:

104 kDa (no GST tag)



Species:

Human



Source:

Bacterial recombinant



Stock:

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol



Concentration:

See tube label



Quality Assurance:

~90% by SDS-PAGE, see datasheet for gel image



Storage:

Store at -80°C; avoid multiple freeze-thaw cycles



PDF Data Sheet:

PDF Datasheet



NCBI RefSeq:

NM_006154.3



Image(s):

(Click image to enlarge)








Coomassie-stained SDS-PAGE
Lane 1: Molecular weight
Marker
s
Lane 2: 5 ?g purified GST-UbE3A (E6AP)







Shipping Method:

Dry ice shipping



References:

1. Cao XR, et al., NEDD4 controls animal growth by regulating IGF-1 signaling. Sci Signal. 1 (38): ra5. 2. Wang X, et al., NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell. 128, 129.




Details

NEDD4 (neural precursor cell expressed developmentally down-regulated protein 4) is a widely expressed HECT domain-containing E3 ubiquitin ligase. NEDD4 ubiquitinates a few membrane proteins, including IGF-1R and PTEN, by which it regulates signal transduction.

Images:
(Click image to enlarge)