商品编号


P4875-1G



品牌


西格玛奥德里奇(Sigma-Aldrich)



公司


Merck & Co., Inc.



公司分类


Chemistry



Size

1G



商品信息

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Synonym:

3,3-Dimethyl-
D
-cysteine, 3-Mercapto-
D
-valine,
D-
(?)-2-Amino-3-mercapto-3-methylbutanoic acid

CAS Number
52-67-5



Linear Formula
(CH
3
)
2
C(SH)CH(NH
2
)CO
2
H



Molecular Weight
149.21



?Beilstein Registry Number
1722375



?EC Number
200-148-8



?MDL number
MFCD00064302



?PubChem Substance ID
24898564




Popular?Documents:??FTIR (PDF)

?

Properties:

Related Categories

Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Biochemicals and Reagents,

Chemical
BIOLOG
y, Chemical Structure Class, Chemical Synthesis, Interferes with Cell Wall Synthesis, L - Z, Mechanism of Action, Penicillamine Derivatives, Penicillins and Cephalosporins (beta-Lactams), Peptide Chemistry, Spectrum of Activity, Unnatural Amino Acids & Derivatives
More...



InChI Key ?

VVNC
NSJ
FMMFHPL-VKHMYHEASA
-N


assay ?

98-101%


mp ?

210?°C (dec.)(lit.)


solubility ?

H
2
O: 100?mg/mL


Mode of action ?

cell wall synthesis | interferes


storage temp. ?

2-8°C


Gene Information ?

mouse ... Oprk1(18387)

Description:
Packaging

5, 25 g in poly bottle

Application

It is used as an antirheumatic and as a chelating agent in Wilson′s disease. It is used as a copper chelator to form mixed disulfides with cysteine or other sulfide media components. It is used to inactivate protein-1 DNA binding
and to inhibit the growth of asynchronous cultures of rabbit articular chondrocytes
.

Biochem/physiol Actions

Penicillamine is a characteristic degradation product of penicillin type antibiotics. One atom of copper combines with two molecules of penicillamine. Penicillamine reduces excess cystine excretion in cystinuria. This is by disulfide interchange between penicillamine and cystine, which results in formation of a re
ADI
ly excreted penicillamine-cysteine disulfide. Penicillamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed. Penicillamine lowers IgM rheumatoid factor and depresses T-cell activity.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.
Safety:

Symbol?


??GHS08



Signal word?


Warning




Hazard statements?

H361d



Precautionary statements?

P280



Personal Protective Equipment?

dust mask type N95 (US), Eyeshields, Gloves



RIDADR?

NONH for all modes of transport



WGK Germany?

2



RTECS?

YV9425000