商品编号


XSTP723PA-1



品牌


SBI



公司


System Biosciences（SBI）



公司分类


exosome engineering


商品信息

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Overview:
Putting exosomes to work: Target exosomes to cancer cells

Use exosomes to deliver protein, RNA, DNA, or small molecule cargo to cells expressing EGFR, such as cancer cells, with XStamp-GE11. The patented XStamp technology is an optimized, exosome surface display system that efficiently places protein sequences on exosomal surfaces. The XStamp-GE11 Lentivector fuses the GE11 peptide to the XStamp tag, ensuring that exosomes display the GE11 peptide on their outer surface. Exosomes made from cells transfected or transduced with the XStamp-GE11 Lentivector will now be targeted to cells expressing EGFR, the receptor for GE11.



Display GE11 sequences on exosome surfaces

Target cancer cells

Create stable XStamp-GE11 cell lines



SBI
also offers a selection of pre-built targeting XStamp Lentivectors, as well as a clone-your-own XStamp Cloning and Expression Vector:




Cat.#

Specificity

Targeting Ligand Used





XSTP710PA-1

Clone-your-own

You decide



XSTP720PA-1

GI tract cells

Motilin



XSTP721PA-1

Neural cells

NCAM



XSTP722PA-1

Brain cells

BHP1



XSTP723PA-1

Cancer cells

GE11



XSTP724PA-1

Breast cancer cells

HER2



XSTP725PA-1

Antigen-presenting cells

CD40L/CD154



XSTP726PA-1

Immune cells

IL-2




How It Works:
Engineering exosomes with specific surface proteins


XStamp is based upon a C-terminal fusion of the C1C2 domain from the protein MFG-E8, which is targeted to the exosome surface. Protein sequences that are fused to the XStamp tag will efficiently display the protein ligand fusion on the surfaces of secreted exosomes.